COPD may boost risk of cerebral microbleeds

From Clinical Neurology News, 19 July 2013:

Chronic obstructive pulmonary disease was associated with an increased risk of cerebral microbleeds – a marker of cerebral small vessel disease – independent of factors such as age, sex, smoking status, and cholesterol levels, according to a prospective, population-based cohort study.

“Depression, postural instability, cognitive and functional impairment are known consequences of cerebral small-vessel disease, and are frequently described extrapulmonary manifestations in patients with COPD,” wrote Dr. Lies Lahousse from Ghent University Hospital, Belgium, and colleagues. “However, it is unclear whether COPD is associated with incident cerebral small-vessel disease.”

Patients with COPD had a significantly higher prevalence of cerebral microbleeds, compared with patients with normal lung function, even after accounting for age, sex, smoking status, atherosclerotic macroangiopathy, antithrombotic use, total cholesterol, triglycerides, and serum creatinine (odds ratio, 1.7; 95% confidence interval, 1.15-2.47; P = .007).

Patients with COPD also had a more than threefold increase in the prevalence of microbleeds in deep or infratentorial locations (OR, 3.3; 95% CI, 1.97-5.53; P less than .001), according to data published online July 19 in the American Journal of Respiratory and Critical Care Medicine. Read more.

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