From Nature Middle East, 6 April 2022: Lewy body disease, or dementia with Lewy bodies, is characterised by a brain build-up of a particular form of the protein alpha-synuclein, forming clumps called aggregates. These aggregates are mostly made up of the phosphorylated form of alpha-synuclein, in which a single amino acid – serine 129 – … Continue reading Rethinking Lewy body dementia
From The Medical Republic, 21 March 2022: There was a time before covid, which seems a distant memory now, when the concepts of “immune” and “immunised” seemed relatively straightforward to anyone outside the field of immunology. Either by virtue of childhood infection or vaccination, a person believed that they were now protected from further assault … Continue reading What do we mean by Covid immunity?
From The Medical Republic, 18 February 2022: “It’s no worse than the flu” has been the rallying cry of covid-deniers, anti-vaccination campaigners, and anyone with a financial or political interest in downplaying the devastating impact that SARS-CoV-2 has had on humanity. While they have been proven spectacularly wrong on so many fronts, there is one … Continue reading Is Covid becoming endemic?
From The Medical Republic, 10 March 2022: Covid can develop resistance to the monoclonal antibody that was thought to be “variant-proof”, Australian research suggests. A research letter published in the New England Journal of Medicine reports on four patients with covid who experienced treatment failure with sotrovimab, and were then found to have variants of … Continue reading Sotrovimab-resistant covid ‘could spread’
From Medscape, 23 November 2021: A large randomized, placebo-controlled trial of platelet-rich plasma injections for knee osteoarthritis has found almost no symptomatic or structural benefit from the treatment, giving some clarity to an evidence base that has seen both positive and negative trials for the treatment modality. Given the need for better disease-modifying treatments for … Continue reading Platelet-rich plasma injections show no benefit in knee OA in placebo-controlled trial
Family Practice News, 15 December 2021: People with multiple preexisting chronic conditions experience a longer wait to receive a diagnosis of cancer and are more likely to be referred to an emergency department for their cancer, according to new research. These findings are based on a retrospective study of data from 11,716 cancer patients from … Continue reading Delays in cancer referral, diagnosis linked with morbidities
From Medscape, 23 November 2021: A large randomized, placebo-controlled trial of platelet-rich plasma injections for knee osteoarthritis has found almost no symptomatic or structural benefit from the treatment, giving some clarity to an evidence base that has seen both positive and negative trials for the treatment modality. Given the need for better disease-modifying treatments for … Continue reading Platelet-Rich Plasma Injections Show No Benefit in Knee OA in Placebo-Controlled Trial
From Nature, 14 October 2021: Infectious-diseases physician Krutika Kuppalli had been in her new job for barely a week in September 2020, when someone phoned her at home and threatened to kill her. Kuppalli, who had just moved from California to the Medical University of South Carolina in Charleston, had been dealing with online abuse … Continue reading ‘I hope you die’: how the COVID pandemic unleashed attacks on scientists
From The Medical Republic, 1 October 2021 When did you last read a study of a new drug or treatment which included any mention of – or even ruled out – potential adverse effects impacts on male fertility? If you’ve been racking your brain for several minutes and still can’t think of one, you’re not … Continue reading Spare a thought for the sperm
From Nature, 25 August 2021: “Dealing with pain is messy,” says John Roberts, an oncologist at the Yale School of Medicine in New Haven, Connecticut. It can’t be measured objectively through biomarkers or visualized on a scan, the experience of it varies enormously from person to person, and it can be fiendishly difficult to treat. … Continue reading Why severe sickle-cell pain has been neglected